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COMMUNICATIONS
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4473-4478
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Highly Potent and Selective Human A3 Adenosine Receptor Antagonists
Pier Giovanni Baraldi,
Barbara Cacciari,
Romeo Romagnoli,
Giampiero Spalluto,
Karl-Norbert Klotz,
Edward Leung,
Katia Varani,
Stefania Gessi,
Stefania Merighi, and
Pier Andrea Borea
[Full Article -
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EXPEDITED ARTICLES
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4479-4484
| Potent and Selective Inhibition of Varicella-Zoster Virus (VZV) by Nucleoside Analogues with an Unusual Bicyclic Base
Christopher McGuigan,
Christopher J. Yarnold,
Garry Jones,
Sonsoles Velázquez,
Hubert Barucki,
Andrea Brancale,
Graciela Andrei,
Robert Snoeck,
Erik De Clercq, and
Jan Balzarini
[Full Article -
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ARTICLES
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4485-4499
| Endothelin Antagonists: Substituted Mesitylcarboxamides with High Potency and Selectivity for ETA Receptors
Chengde Wu,
E. Radford Decker,
Natalie Blok,
Huong Bui,
Qi Chen,
B. Raju,
Andree R. Bourgoyne,
Vippra Knowles,
Ronald J. Biediger,
Robert V. Market,
Shuqun Lin,
Brian Dupré,
Timothy P. Kogan,
George W. Holland,
Tommy A. Brock, and
Richard A. F. Dixon
[Full Article -
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4500-4505
| Design of MKC-442 (Emivirine) Analogues with Improved Activity Against Drug-Resistant HIV Mutants
Andrew L. Hopkins,
Jingshan Ren,
Hiromichi Tanaka,
Masanori Baba,
Mika Okamato,
David I. Stuart, and
David K. Stammers
[Full Article -
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4506-4523
| Affinity and Selectivity of Matrix Metalloproteinase Inhibitors: A Chemometrical Study from the Perspective of Ligands and Proteins
Hans Matter and
Wilfried Schwab
[Full Article -
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4524-4537
| Angiotensin II Analogues Encompassing 5,9- and 5,10-Fused Thiazabicycloalkane Tripeptide Mimetics
Petra Johannesson,
Gunnar Lindeberg,
Weimin Tong,
Adolf Gogoll,
Barbro Synnergren,
Fred Nyberg,
Anders Karlén, and
Anders Hallberg
[Full Article -
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4538-4546
| Molecular Modeling Studies on G-Quadruplex Complexes of Telomerase Inhibitors: Structure-Activity Relationships
Martin A. Read,
Alexis A. Wood,
John R. Harrison,
Sharon M. Gowan,
Lloyd R. Kelland,
Harvinder S. Dosanjh, and
Stephen Neidle
[Full Article -
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4547-4562
| Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors
Neil G. Almstead,
Rimma S. Bradley,
Stanislaw Pikul,
Biswanath De,
Michael G. Natchus,
Yetunde O. Taiwo,
Fei Gu,
Lisa E. Williams,
Barbara A. Hynd,
Michael J. Janusz,
C. Michelle Dunaway, and
Glen E. Mieling
[Full Article -
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4563-4571
| Metabolism-Based Brain-Targeting System for a Thyrotropin-Releasing Hormone Analogue
Laszlo Prokai,
Katalin Prokai-Tatrai,
Xudong Ouyang,
Ho-Seung Kim,
Whei-Mei Wu,
Alevtina Zharikova, and
Nicholas Bodor
[Full Article -
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4572-4583
| Specific Nonpeptide Photoprobes as Tools for the Structural Study of the Angiotensin II AT1 Receptor
Sandrine Nouet,
Pierre R. Dodey,
Michel R. Bondoux,
Didier Pruneau,
Jean-Michel Luccarini,
Thierry Groblewski,
Renée Larguier,
Colette Lombard,
Jacky Marie,
Patrice P. Renaut,
Gérard Leclerc, and
Jean-Claude Bonnafous
[Full Article -
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4584-4603
| Design and Synthesis of Thrombin Inhibitors: Analogues of MD-805 with Reduced Stereogenicity and Improved Potency
Derek Brundish,
Alice Bull,
Vera Donovan,
Joseph D. Fullerton,
Sheila M. Garman,
Judy F. Hayler,
Diana Janus,
Peter D. Kane,
Mark McDonnell,
Garrick P. Smith,
Robert Wakeford,
Clive V. Walker,
Graham Howarth,
William Hoyle,
Mark C. Allen,
John Ambler,
Keith Butler, and
Mark D. Talbot
[Full Article -
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4604-4613
Solution Structure of Polymyxins B and E and Effect of Binding to Lipopolysaccharide: An NMR and Molecular Modeling Study
Primo Pristov ek and
Jurka Kidri
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4614-4620
| C60 and Water-Soluble Fullerene Derivatives as Antioxidants Against Radical-Initiated Lipid Peroxidation
I Chen Wang,
Lin Ai Tai,
Don Dar Lee,
P. P. Kanakamma,
Clifton K.-F. Shen,
Tien-Yau Luh,
Chien Hong Cheng, and
Kuo Chu Hwang
[Full Article -
PDF]
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4621-4629
Asymmetric Synthesis of 9-Alkyl-2-benzyl-6,7-benzomorphans: Characterization as Novel  Receptor Ligands
F. Ivy Carroll,
Xu Bai,
Ali Dehghani,
S. Wayne Mascarella,
Wanda Williams, and
Wayne D. Bowen
[Full Article -
PDF]
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4630-4639
| Structural Specificity of Chloroquine-Hematin Binding Related to Inhibition of Hematin Polymerization and Parasite Growth
Sudha Rani Vippagunta,
Arnulf Dorn,
Hugues Matile,
Apurba K. Bhattacharjee,
Jean M. Karle,
William Y. Ellis,
Robert G. Ridley, and
Jonathan L. Vennerstrom
[Full Article - PDF]
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4640-4649
| 3-O-Desacyl Monophosphoryl Lipid A Derivatives: Synthesis and Immunostimulant Activities
David A. Johnson,
David S. Keegan,
C. Gregory Sowell,
Mark T. Livesay,
Craig L. Johnson,
Lara M. Taubner,
Annalivia Harris,
Kent R. Myers,
Jennifer D. Thompson,
Gary L. Gustafson,
Michael J. Rhodes,
J. Terry Ulrich,
Jon R. Ward,
Yvonne M. Yorgensen,
John L. Cantrell, and
Valerie G. Brookshire
[Full Article - PDF]
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4650-4658
Predicting Binding Affinities of Protein Ligands from Three-Dimensional Models: Application to Peptide Binding to Class I Major Histocompatibility Proteins
Didier Rognan,
Sanne Lise Lauem ller,
Arne Holm,
Sren Buus, and
Vincenzo Tschinke
[Full Article - PDF]
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4659-4668
| 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1 Receptor Antagonists: Structural Modifications at the Tryptophan Domain
José M. Bartolomé-Nebreda,
Isabel Gómez-Monterrey,
M. Teresa García-López,
Rosario González-Muñiz,
Mercedes Martín-Martínez,
Santiago Ballaz,
Edurne Cenarruzabeitia,
Miriam LaTorre,
Joaquín Del Río, and
Rosario Herranz
[Full Article - PDF]
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4669-4679
| Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation
Manfred Jung,
Gerald Brosch,
Doris Kölle,
Hans Scherf,
Clarissa Gerhäuser, and
Peter Loidl
[Full Article - PDF]
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4680-4694
| Discovery of Novel Non-Peptide CCR1 Receptor Antagonists
Howard P. Ng,,1
Karen May,
John G. Bauman,
Ameen Ghannam,
Imadul Islam,
Meina Liang,
Richard Horuk,
Joseph Hesselgesser,
R. Michael Snider,
H. Daniel Perez, and
Michael M. Morrissey
[Full Article - PDF]
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4695-4704
| LASSOO: A Generalized Directed Diversity Approach to the Design and Enrichment of Chemical Libraries
Ryan T. Koehler,
Steven L. Dixon, and
Hugo O. Villar
[Full Article - PDF]
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4705-4713
| Structure-Activity Relationships of Novel 2-Substituted Quinazoline Antibacterial Agents
Pei-Pei Kung,
Martin D. Casper,
Kimberley L. Cook,
Laura Wilson-Lingardo,
Lisa M. Risen,
Timothy A. Vickers,
Ray Ranken,
Lawrence B. Blyn,
Jacqueline R. Wyatt,
P. Dan Cook, and
David J. Ecker
[Full Article - PDF]
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4714-4719
| Vancomycin Binding to Low-Affinity Ligands: Delineating a Minimum Set of Interactions Necessary for High-Affinity Binding
Patrick J. Loll,
Jeffrey Kaplan,
Barry S. Selinsky, and
Paul H. Axelsen
[Full Article - PDF]
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BRIEF ARTICLES
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4720-4724
| Synthesis and Pharmacological Evaluation of Some 8-Cyanopyrido[3',2':4,5]thieno[3,2-d]triazine Derivatives as Inhibitors of Nitric Oxide and Eicosanoid Biosynthesis
José Ma Quintela,
Carlos Peinador,
Liliana Ma González,
Ricardo Riguera,
Inmaculada Rioja,
Ma Carmen Terencio,
Amalia Ubeda, and
Ma José Alcaraz
[Full Article - PDF]
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4725-4728
Inhibition and Substrate Activity of Conformationally Rigid Vigabatrin Analogues with  -Aminobutyric Acid Aminotransferase
Jian Qiu,
Joyce M. Pingsterhaus, and
Richard B. Silverman
[Full Article - PDF]
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4729-4732
| Synthesis and Biological Evaluation of the First N-Alkyl Cage Dimeric 4-Aryl-1,4-dihydropyridines as Novel Nonpeptidic HIV-1 Protease Inhibitors
Andreas Hilgeroth,
Michael Wiese, and
Andreas Billich
[Full Article - PDF]
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